INVITED SPEAKERS

 

Marco Ferrazzoli



Dr. Ferrazzoli obtained a Degree in Literature (La Sapienza University), a
Master in Consultation Psychology (The European University of Rome) and a
Master in Institutional Communication (Rome Tor Vergata University). He heads
the press office of the Italian National Research Council (CNR), and is the
editorial director of the web magazine Almanacco della Scienza. Dr. Ferrazzoli
is also head of the CNR website and director of the CNR Web Tv.
Dr. Ferrazzoli teaches “Theory and technique of the dissemination of knowledge”
at Rome Tor Vergata University and is the author of several publications and
books, including “Parola di scienziato. La conoscenza ridotta a opinione”
(Universitalia, Roma 2014).

At the BraYn Conference, Dr. Ferrazzoli will present a speech titled “The lay
scientist: scientific knowledge has become an opinion”.

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Rosa C. Paolicelli


 
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Rosa C. Paolicelli earned her bachelor of Medical Biotechnology at the University of Bologna, Italy, in 2006, and her MSc in Molecular Neuroscience at the University of Bristol, UK, in 2007. She graduated in 2011 with a PhD in Cellular and Molecular Biology, from the European Molecular Biology Laboratory (EMBL). In her predoctoral work, Dr. Paolicelli investigated the role of microglia in refining neural circuits during development, showing that synaptic pruning by microglia is critical for proper brain maturation. After completing her PhD, Dr. Paolicelli worked as postdoc at the University of Zurich, Switzerland, in the Department of Systems and Cell Biology of Neurodegeneration (2012-2018). During this time, she investigated the cellular and molecular mechanisms underlying microglia-mediated synapse loss in neurodegenerative diseases. By using a combination of in vitro and in vivo approaches, Dr. Paolicelli showed that aberrantly phagocytic microglia can lead to excessive synapse removal, thus providing evidence that dysfunctional microglia can be implicated in the pathogenesis of neurodegeneration. Dr. Paolicelli recently got a position as Assistant Professor (2018) at the University of Lausanne, Switzerland, where she is establishing her lab on microglia biology, focusing on the molecular mechanisms regulating microglia-synapse interaction in physiological and pathological contexts. 

At BraYn conference, she will present a talk titled "Microglia-mediated synapse loss in neurodegeneration". For more info about Rosa C. Paolicelli and her institution, please click here.

 

Matthew Campbell


Dr. Matthew Campbell graduated from University College Dublin (UCD) in 2006 with a PhD in Biochemistry followed by Post-doctoral research in Trinity College Dublin (TCD) in Human Molecular Genetics (2006-2012). He has published extensively on the use of RNA interference (RNAi) to modulate levels of distinct tight junction proteins at the blood-brain barrier/inner blood retina barrier (BBB/iBRB) in vivo. Additionally, he has published numerous articles focused on understanding the molecular pathology of diseases such as age-related macular degeneration (AMD), Alzheimer's disease, Schizophrenia, traumatic brain injury (TBI) and chronic traumatic encephalopathy (CTE).  He leads the Neurovascular Genetics Research group based in the Smurfit Institute of Genetics at TCD where he is also a lecturer in Human Genetics.

In 2013, he was awarded Science Foundation Ireland's (SFI) most prestigious prize for young researchers, the President of Ireland Young Researcher Award (PIYRA) in relation to his BBB based research.  In the same year, he was awarded the Genentech/ARVO research fellowship for his ophthalmology focused work related to AMD.  This work led to numerous papers including Nature Medicine (2012, 2014) and Science Translational Medicine (2014) describing the therapeutic potential for IL-18 and its use in treating patients with wet AMD.

At the BraYn conference, he will present a talk titled “ Regulation of the blood-brain barrier in health and neurodegenerative disease”. For more info about Dr. Matthew Campbell and his institution, please click here

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Nunzio Iraci


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Dr Nunzio Iraci (NI) graduated with a MSc in Pharmaceutical Biotechnology (2005) and a PhD in Cellular Biology and Physiology (2009), both from the University of Bologna, Italy. His previous studies have defined the mechanism by which the v-myc myelocytomatosis viral related oncogene (MYCN) represses the transcription of nerve growth factor (NGF) receptors in human neuroblastoma. NI moved to the Dept. of Clinical Neurosciences at the University of Cambridge (UK) in 2011 and was awarded a FEBS Long-Term Fellowship. His research focussed on the mechanisms of cell-to-cell communication mediated by neural stem cell (NSC)-derived extracellular vesicles (EVs). With his work NI contributed to demonstrate that: (i) NSCs secrete EVs mainly comprising of exosomes; (ii) mRNA and protein sorting in EVs/exosomes is regulated by inflammatory cytokines; (iii) IFN-γ/Ifngr1 complex on EVs promotes the intercellular induction of Stat1 signalling; (iv) EVs are metabolically active and alter enzymatically the metabolic environment; (v) mouse and human NSC-derived EVs are enriched in L-asparaginase activity (via Asrgl1). Taken together these results revealed a mechanism of intercellular signaling by which neural stem cells may signal with the microenvironment via EVs, both in physiological conditions and in the context of neurodegenerative diseases. In 2016 NI moved to the University of Catania with a tenure-track position as Assistant Professor of Molecular Biology. Here he is responsible as Principal Investigator of a “Brains2South” grant aiming at the characterization of exosomes as natural messengers of bioactive molecules in the glial-neuronal signaling in the context of Parkinson's disease.

At BraYn conference, he will present a talk titled " Extracellular vesicles as a novel strategy of cell-to-cell communication". For more info about Nunzio Iraci's research, please click here.